Figure 1. Daily number of confirmed COVID-19 cases in Uttar Pradesh between 4 March 2020 and 5 October 2021. Daily new confirmed cases are presented as the rolling 7-day average. Data and image from covid19india.org.
“The Indian Council of Medical Research, funded by the government, recommended ivermectin for COVID-19 in May 2021, but reversed this recommendation in September, citing lack of evidence.”
Figure 1. Daily number of confirmed COVID-19 cases in Uttar Pradesh between 4 March 2020 and 5 October 2021. Daily new confirmed cases are presented as the rolling 7-day average. Data and image from covid19india.org.
“The Indian Council of Medical Research, funded by the government, recommended ivermectin for COVID-19 in May 2021, but reversed this recommendation in September, citing lack of evidence.”
Uttar Pradesh government says early use of Ivermectin helped to keep positivity, deaths low
-uws(United We Stand);
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Written by Maulshree Seth Lucknow | May 12, 2021 10:02:08 am
The state Health Department introduced Ivermectin as prophylaxis for close contacts of Covid patients, health workers as well as for the treatment of the patients themselves through a government order on August 6, 2020. (Wikimedia Commons)
A year after the country’s first Covid-19 cluster, with 5 cases, was reported in Agra district, the Uttar Pradesh government has claimed that it was the first state to have introduced a large-scale “prophylactic and therapeutic” use of Ivermectin and added that the drug helped the state to maintain a lower fatality and positivity rate as compared to other states.
Citing the results from Agra in the month of May and June last year, following which the use of Ivermectin, a medicine to treat parasitic ailments, along with Doxycycline was introduced as a protocol across the state for both prophylactic as well as treatment purposes, the state Health Department said it would conduct a controlled study once the second wave of the pandemic subsides.
The state Health Department introduced Ivermectin as prophylaxis for close contacts of Covid patients, health workers as well as for the treatment of the patients themselves through a government order on August 6, 2020, after a committee headed by the Director General, Medical and Health Services, gave it the go ahead.
“Uttar Pradesh was the first state in the country to introduce large-scale prophylactic and therapeutic use of Ivermectin. In May-June 2020, a team at Agra, led by Dr Anshul Pareek, administered Ivermectin to all RRT team members in the district on an experimental basis. It was observed that none of them developed Covid-19 despite being in daily contact with patients who had tested positive for the virus,” Uttar Pradesh State Surveillance Officer Vikssendu Agrawal said.
He added that based on the findings from Agra, the state government sanctioned the use of Ivermectin as a prophylactic for all the contacts of Covid patients and later cleared the administration of therapeutic doses for the treatment of such patients.
Claiming that timely introduction of Ivermectin since the first wave has helped the state maintain a relatively low positivity rate despite its high population density, he said, “Despite being the state with the largest population base and a high population density, we have maintained a relatively low positivity rate and cases per million of population”.
He said that apart from aggressive contact tracing and surveillance, the lower positivity and fatality rates may be attributed to the large-scale use of Ivermectin use in the state, adding that the drug has recently been introduced in the National Protocol for Covid treatment and management. “Once the second wave subsides, we would conduct our own study as there has been an emerging body of evidence to substantiate our timely use of Ivermectin from the first wave itself,” Vikasendu told The Indian Express.
Agra District Magistrate Prabhu N Singh also attributed the state’s relative success in keeping the Covid numbers down to the timely nod to the use of Ivermectin as a prophylactic. He added that government doctor Anshul Pareek had approached him last year citing use of the medicine abroad.
“We reported the first Covid-19 cluster in the country after five members of a family, who had returned from Italy, tested positive. Soon, the virus spread, with a large number of police personnel getting affected. Doctor Pareek approached me with a request to introduce Ivermectin on an experimental basis. I was told there are no risks involved with the use of the drug,” Singh told The Indian Express.
He said the district administration had formed small groups of personnel from the same police station as well staffers at his office. “We introduced it (Ivermectin) for three days, 12 mg as advised in the national guidelines at the time, followed by tests on the fourth or fifth day. We introduced it in the jail as well and the results helped us reduce positivity to a great extent, following which Additional Chief Secretary Health Amit Mohan formed a committee to access its usage and it was finally introduced in the state’s Covid management protocol in 2020 itself,” Singh said.
Claiming that timely introduction of Ivermectin since the first wave has helped the state maintain a relatively low positivity rate despite in its high population density.
Meta-analyses based on 18 randomized controlled treatment trials of ivermectin in COVID-19 have found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance.
-blueskygg(Grass);
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After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective treatment options. In addition, a multitude of both novel and repurposed therapeutic agents ...
这个文章抬头有一段话“ THIS ARTICLE HAS BEEN CORRECTED.See the correction in volume 28 on page 813”，没给link上。不过这里有一篇文章交代了一些背景。可以看看。似乎是base的数据有问题被retract了，这个杂志的编辑issue 了expression of concern
-kittywhy(kittywhy);
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排除掉其中一个有争议的研究，结果不变。we decided to redo the original meta-analyses excluding this study. The summary point estimates were largely unaffected when the study by Elgazzar et al was removed.
-blueskygg(Grass);
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An Illinois family whose loved one was "desperately ill" and hospitalized earlier this month with COVID-19 says he's now home and doing well after a judge had to order a Naperville hospital to treat him with Ivermectin.
