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果然厉害Fig. 5. Identification and characterization of a broadly neutralizing...

firetrain(火车头)
Download scientific diagram | Identification and characterization of a broadly neutralizing monoclonal antibody from Smg immunized mice. a, FACS showing the percentage of spike-specific B cells from mice immunized with Sfg or Smg at day 28 after the last immunization. b, The relative ratio of the percentage of S-specific B cells (CD3 − CD19 + S + ) vs. negative staining (without S) in the spleen of immunized mice or naïve mice (n=5). c, FACS analysis of m31A7 binding with 293T cells expressing S protein of WH01 and various variants. d, ELISA showing m31A7 binding to S1, S2, or RBD of the S protein. from publication: Impact of Glycosylation on SARS-CoV-2 Infection and Broadly Protective Vaccine Design | A major challenge to end the pandemic caused by SARS-CoV-2 is to develop a broadly protective vaccine. As the key immunogen, the spike protein is frequently mutated with conserved epitopes shielded by glycans. Here, we reveal that spike glycosylation has site-differential... | Vaccine Development, COVID-19 and Protection | ResearchGate, the professional network for scientists.
Full Story:
https://www.researchgate.net/figure/Identification-and-characterization-of-a-broadly-neutralizing-monoclonal-antibody-from_fig5_351875251
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Last Updated: 2022-1-10
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Replies, comments and Discussions:

  • 枫下家园 / 医药保健 / 好消息！台湾中研院已经开发出了广效疫苗，对所有变种都有效。不想打mRNA的等一等很快就有真正的疫苗了。春天快了！ -pili(小黑); 2022-1-10 (#14259853@0)
    • 有效性本来就问题不大,关键是有效期 -xiaozuiba(xiaozuiba); 2022-1-10 (#14259855@0) +1
      • 现在的mRNA疫苗对omicron是无效的。最早三月辉瑞和莫德纳才能推出新的疫苗对付这个变种。如果有新变种，mRNA会再次失效，这是它的原理决定的。 -pili(小黑); 2022-1-10 (#14259867@0) +2
        • 你被反疫苗人士成功洗脑了 -xiaozuiba(xiaozuiba); 2022-1-10 (#14260494@0) +2
          • 😄 -pili(小黑); 2022-1-10 (#14260498@0)
    • 這個研究計劃的主持人, 翁啓惠,目前是諾貝爾化學獎呼聲非常高的候選人,諾獎的所有預備奬, 翁啓惠已經全部囊括,是非常有實力的研究人員 -youarenotfunnyatall(草山); 2022-1-10 {214} (#14259971@0)


      :

      • 果然厉害Fig. 5. Identification and characterization of a broadly neutralizing... -firetrain(火车头); 2022-1-10 {2119} (#14260418@0)
        Download scientific diagram | Identification and characterization of a broadly neutralizing monoclonal antibody from Smg immunized mice. a, FACS showing the percentage of spike-specific B cells from mice immunized with Sfg or Smg at day 28 after the last immunization. b, The relative ratio of the percentage of S-specific B cells (CD3 − CD19 + S + ) vs. negative staining (without S) in the spleen of immunized mice or naïve mice (n=5). c, FACS analysis of m31A7 binding with 293T cells expressing S protein of WH01 and various variants. d, ELISA showing m31A7 binding to S1, S2, or RBD of the S protein. from publication: Impact of Glycosylation on SARS-CoV-2 Infection and Broadly Protective Vaccine Design | A major challenge to end the pandemic caused by SARS-CoV-2 is to develop a broadly protective vaccine. As the key immunogen, the spike protein is frequently mutated with conserved epitopes shielded by glycans. Here, we reveal that spike glycosylation has site-differential... | Vaccine Development, COVID-19 and Protection | ResearchGate, the professional network for scientists.
        Full Story:
        https://www.researchgate.net/figure/Identification-and-characterization-of-a-broadly-neutralizing-monoclonal-antibody-from_fig5_351875251
        • 已經拿到美國的專利,不採用易變異的棘突蛋白特徵,而用專利技術,採用聚醣下面所覆蓋的部分,既不異變異,且能露出更多可供辨認的特徵，能夠讓疫苗產生數量更多且更多樣化的抗體 -youarenotfunnyatall(草山); 2022-1-10 (#14260541@0) +2
          • 药不让申请专利吧 -utgfxval3(蛙); 2022-1-10 (#14260815@0)
            • 藥物專利各國都有,美國藥物專利甚至分化學藥物和生物藥物 -youarenotfunnyatall(草山); 2022-1-10 (#14260875@0)
      • 留有余地,前几个月台湾就研发高效的单抗株,但后来就没啥动静了 -xiaozuiba(xiaozuiba); 2022-1-10 (#14260432@0) +1
        • 7月宣布的是同一個東西, 單醣化蛋白 -youarenotfunnyatall(草山); 2022-1-10 (#14260528@0) +1
      • 美国这次犯的最大错误就是轻视了台湾 -pili(小黑); 2022-1-10 (#14260490@0)
        • 拿了美國專利,才正式在上月底公布,會不會用在新冠難說,但是應該會是下一代流行性病毒疫苗主力,台灣已經有高端的次蛋白疫苗在聯合國等3期結果 -youarenotfunnyatall(草山); 2022-1-10 (#14260558@0) +3
    • 历害国马上也会宣称开发出新疫苗。哈哈 -maya1(great); 2022-1-10 (#14260468@0) +1
      • 啥意思？你以为台湾这个也是骗子？ -pili(小黑); 2022-1-10 (#14260495@0) +2
        • 就是个骗子 -giss(rr); 2022-1-10 (#14260884@0) +8
          • 你啥毛病？ -youarenotfunnyatall(草山); 2022-1-10 (#14260890@0) +2

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